Le laboratoire SABNP, organise un conférence scientifique sur le thème suivant :
« Decrypting the codes for nuclear control of gene expression in organelles«
Intervenant :
Charles ROBERT
Laboratoire de Biochimie Théorique
Institut de Biologie Physico Chimique
Résumé :
Mitochondria and chloroplasts in eukaryotic cells arose from endosymbiosis of primitive prokaryotes more than a billion years ago. Along the course of evolution, the cell nucleus gradually assumed control of their gene expression, employing nuclear-encoded proteins that enter the organelle and bind their mRNA sequence-specifically. These proteins fold with an alpha-solenoid architecture comprised of tandem repetitions of degenerate 35-residue (pentatricopeptide repeat, or PPR) or 38-residue (octotricopeptide repeat, or OPR) motifs. In the last fifteen years or so, researchers have identified important determinants of specific recognition in these systems, but the resulting recognition « codes » are incomplete. The first results of our recent collaboration coupling comparative genomics of micro-algae and molecular dynamics simulation suggest new avenues towards refining the PPR- and OPR-mRNA recognition codes and better understanding of the coevolution of the nuclear and chloroplast genomes in eukaryotic organisms.
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